The mechanism of action of Levofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination. Approximately 80% of patients experienced at least one adverse event in both groups. If it is necessary to take lithium with this medicine, your doctor should carefully monitor your blood level of lithium. Medical problems among ICSOM musicians: overview of a national survey”. Ranitidine is a competitive, reversible inhibitor of the action of histamine at the histamine H 2 receptors found in gastric parietal cells. This combination has been developed for the management of patients with type 2 diabetes mellitus who are intolerant or not adequately controlled with metformin monotherapy, and has been approved in the US and EU.
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