Apart from the fact that these medicines may not work, there is also the risk of potentially serious adverse effects from taking non-genuine medicines. Lamotrigine reduces the frequency of LGS seizures, and is one of two medications known to decrease the severity of drop attacks. In general, use a low initial starting dose in elderly patients given their greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. The metabolism of Ondansetron can be decreased when combined with Efavirenz. However, the brand-name version might not be stocked at every pharmacy. A number of case reports and case series have supported a role for oral LEV in the treatment of acute repetitive seizures and status epilepticus that were refractory to initial therapy ( Rossetti and Bromfield 2005 ; Zaatreh 2005 ; Patel et al 2006 ; Rossetti and Bromfield 2006 ; Rupprecht et al 2007 ; Trabacca et al 2007 ; Alehan et al 2008).
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